This study will also evaluate the antitumor effect of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. 2020 Jun;26(6):878-885. doi: 10.1038/s41591-020-0880-x. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. The other main function of the pancreas is to aid with digestion. When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. Clinical trials are research studies that involve people. BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial Nat Med. Patients and methods: In this randomized phase III trial in 16 centers, patients with resectable or borderline resectable pancreatic cancer … The … Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Patients will be assigned to different baskets according to tumor type and gene fusion. In each cohort, eligible patients will be assigned to one of several treatment arms. For example, NCI money for pancreatic cancer research rose from $17 million in 1999 to more than $178 million in 2017. Location: 13 locations, The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil / leucovorin (5FU / LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for metastatic pancreatic cancer. Imaging tests that create pictures of your internal organs. There are two parts to this study. Contrary to the heart or the lungs, which we feel every day working in our bodies, the pancreas is a silent gland that rarely gets mentioned. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12 / 19 / 2017) 24. As with most other types of cancer, pancreatic cancer occurs when cells in the pancreas begin to grow and divide at an abnormal and uncontrolled rate, forming one or several growths called tumors. Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. Clear cell ovarian cancer (closed to accrual) 46. As a result, cells are more likely to develop additional genetic alterations that can lead to some types of cancer, including pancreatic cancer. PARP inhibitors are a type of targeted therapy. Clinical trials look at new ways to prevent, detect, or treat disease. However, a direct relationship between pancreatic cancer and these factors has yet to be established. Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract.) Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Policylab.us does not take responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Odontogenic malignant tumors 22. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. Paraganglioma (closed to accrual 11 / 29 / 2018) 26. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) Giving anetumab ravtansine together with nivolumab, ipilimumab, and gemcitabine hydrochloride may work better in treating patients with pancreatic cancer. The pancreas is a located in the abdomen, nestled between the stomach, the spleen, the small intestine, and the gallbladder, and it plays a crucial role in regulating your blood sugar levels. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 52). Pancreatic Cancer Therapeutics Clinical Trials… Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. Location: 15 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. Location: 11 locations, This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Funding by other agencies and organizations has made similar leaps. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. With stronger support, pancreatic cancer research … Clinical trials are a key component of the “Right Track” model – which encourages cancer patients to see a specialist, get testing and get treatment based on their biology and/or through a clinical trial – for better outcomes. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. But for people with pancreatic cysts or a family history of pancreatic cancer, some screening steps might help detect a problem early. Location: 13 locations, This is a Phase I / II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. This trial enrolls participants for the following cohorts based on condition: 1. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations. Location: 482 locations, This phase III trial compares perioperative chemotherapy (given around the time of surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable / resectable). PD-L1 amplified tumors 50. 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